sGC Stimulators and Activators
نویسندگان
چکیده
منابع مشابه
sGC activators and stimulators attenuate ischemia/reperfusion injury of the lung
Background Protective effects of NO, a physiological activator of soluble guanylyl cyclase (sGC), have been reported in ischemia/reperfusion syndrome (I/R) of the lung. However, its protective effects can be overwhelmed by its deleterious effects due to oxidative products formation. Therefore, we studied the effects of direct sGC stimulator (BAY 41-2272) and sGC activator (BAY 58-2667) on I/R i...
متن کاملNew clinical results with sGC stimulators
Background Stimulators of the nitric oxide (NO) receptor soluble guanylate cyclase (sGC) are a new class of substances which enhance the biosynthesis of cyclic guanosin monophosphate (cGMP) independently from the presence of nitric oxide (NO). In pulmonary smooth muscle cells, increased intracellular cGMP concentrations lead to vasodilatation, making sGC-stimulators potentially useful for the t...
متن کاملStructural insights into sGC activation by different activators
Background The soluble guanylyl cyclase (sGC) is a key enzyme involved in the production of the second messenger cGMP. Due its cardiovascular relevance, sGC has been the target of numerous drug discovery efforts leading to the development of many different activators and stimulators with pharmaceutical potential. One of such compounds is the sGC activator Cinaciguat (BAY 58-2667) which is in cl...
متن کاملNO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272
BACKGROUND The most important receptor for nitric oxide is the soluble guanylate cyclase (sGC), a heme containing heterodimer. Recently, a pyrazolopyridine derivative BAY 41-2272, structurally related to YC-1, was identified stimulating soluble guanylate cyclase in an NO-independent manner, which results in vasodilatation and antiplatelet activity. The study described here addresses the identif...
متن کاملEffects of PDE5 Inhibitors and sGC Stimulators in a Rat Model of Artificial Ureteral Calculosis
Urinary colics from calculosis are frequent and intense forms of pain whose current pharmacological treatment remains unsatisfactory. New and more effective drugs are needed to control symptoms and improve stone expulsion. Recent evidence suggested that the Nitric Oxide (NO) / cyclic guanosine monophosphate (cGMP)/phosphodiesterase type 5 (PDE5) system may contribute to ureteral motility influe...
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ژورنال
عنوان ژورنال: International Cardiovascular Forum Journal
سال: 2019
ISSN: 2409-3424,2410-2636
DOI: 10.17987/icfj.v18i0.609